Genetic epidemiology: Juvenile idiopathic arthritis genetics - What's new? What's next?

R202Q Mutation of Mediterranean Fever Gene in Iranian patients with Systemic-onset Juvenile Idiopathic Arthritis

Background: Systemic-onset Juvenile Idiopathic Arthritis (SoJIA) is an autoinflammatory disease with complex genetic trait starts in children less than 16 years of age with fever and cutaneous rash. Despite, the main genetic factors that may play a role in SoJIA have not yet been identified. High level of interleukin-1beta in the blood of SoJIA patients has been reported. The production and sec...

Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment

Systemic juvenile idiopathic arthritis (sJIA) constitutes a small part of juvenile idiopathic arthritis (JIA), yet has a disproportionally higher rate of mortality. Despite being grouped under JIA, it is considered to be a multifactorial autoinflammatory disease. The objective of this paper is to review the epidemiology, pathogenesis, genetics, clinical manifestations, complications, therapy, p...

Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) is a multifactorial disease with a pathogenesis which remains inexplicable. However, genome-wide association studies brought forward within recent years have discovered several new susceptibility genes, and accumulating evidence supports genetic variability as playing a key role in JIA development. This review summarises the present knowledge of human leukocy...

Growth Assessment and Vitamin D Level in Egyptian Juvenile Idiopathic Arthritis Patients

Background Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic diseases in childhood and is frequently associated with growth retardation. Vitamin D is critical to bone mineral metabolism and to the growth and development of the skeleton. We aimed to...

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